General Information

About Metapsy

Metapsy is a research project led by the VU University Amsterdam (Prof. Pim Cuijpers). The goal of Metapsy is to provide access to meta-analytic databases of clinical trials investigating the effect of psychological interventions (e.g. psychotherapy, preventive interventions, psychoeducation) on various mental disorders or mental health problems.

A Unified Framework of Meta-Analytic Databases

Metapsy aims to provide a unified framework for all available meta-analytic data across different indications and settings. All meta-analytic databases…

Overall, the Metapsy project tries to make meta-analytic psychotherapy research more transparent, flexible, and accessible. We want to facilitate a move from single, isolated meta-analyses toward a collection of meta-analytic research domains (MARDs), thus benefitting both research and practice.

Introducing Meta-Analytic Research Domains

Metapsy aims to serve as a centralized hub for meta-analytic research domains (MARDs; Cuijpers, Miguel, Papola, Harrer & Karyotaki, 2022).

MARDs are living systematic reviews of an entire research domain. In contrast to conventional systematic reviews and meta-analyses, MARDs do not focus on one specific population, intervention, comparison, or outcome (PICO), but on an entire research field that is too broad to be covered by one meta-analysis.

Countless randomized controlled trials and meta-analyses are published each year. This makes it increasingly difficult to keep track of all existing evidence and draw actionable conclusions from it. MARDs provide a higher level of aggregation, in which all relevant evidence in a research field is provided in a consistent, transparent, and re-usable manner.

Like living systematic reviews, MARDs are updated regularly and therefore provide up-to-date evidence; but the scope of MARDs is much larger than what can be covered in one “living” meta-analysis or systematic review.

Like umbrella reviews, MARDs can cover a whole research field. However, MARDs do not “lag behind” like umbrella reviews. Furthermore, information included in MARDs is established using transparent and consistent standards, and can be easily reused or repurposed by the entire research community. Other advantages of MARDs include:

  • πŸ—‘οΈ Reduction of research waste. In the biomedical field, a great amount of redundant, misleading, and biased research is produced on a regular basis (MacLeod et al., 2014). This is also the case in psychotherapy research (Cristea & Naudet, 2019). By centralizing all available evidence, unnecessary work can be avoided. Transparent and consistent standards can lead to more trustworthy findings.
  • πŸ—ΊοΈ Evidence Mapping. MARDs provide an overview of limitations and gaps in knowledge and make it possible to see emerging trends in the field
  • πŸ”Ž Meta-Research (“Research on Research”). MARDs allow examining the methods and research practices of an entire field, and how they changed over time.
  • 🀝 Stakeholders outside the scientific community. MARDs can enable just-in-time evidence generation for specific research questions. This can be used by e.g. treatment guideline developers or clinicians, to get an overview of the current evidence.
  • πŸ”“ Open Science. MARDs provide data in a transparent, accessible, and interoperable way. This allows other members of the scientific community to re-use or repurpose the provided information.

A presentation introducing the concept of meta-analytic research domains.